Microbial genomics as a guide to drug discovery and structural elucidation: ECO-02301, a novel antifungal agent, as an example.

@article{McAlpine2005MicrobialGA,
  title={Microbial genomics as a guide to drug discovery and structural elucidation: ECO-02301, a novel antifungal agent, as an example.},
  author={James B McAlpine and Brian O Bachmann and Mahmood Piraee and Steve Tremblay and Anne-marie Alarco and Emmanuel Zazopoulos and Chris M. Farnet},
  journal={Journal of natural products},
  year={2005},
  volume={68 4},
  pages={
          493-6
        }
}
  • James B McAlpine, Brian O Bachmann, +4 authors Chris M. Farnet
  • Published in Journal of natural products 2005
  • Biology, Medicine
  • Analysis of the genome of Streptomyces aizunensis NRRL B-11277 indicated its potential to produce a compound of novel and highly predictable structure. The structure was predicted with sufficient accuracy to allow straightforward detection of the specific metabolite in HPLC profiles of fermentation extracts and hence to guide the isolation. The spectroscopic work was reduced to a confirmation of structure rather than a first principle determination. The compound, ECO-02301 (1), demonstrated… CONTINUE READING

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