Microbial genomics and novel antibiotic discovery: new technology to search for new drugs.

@article{Dougherty2002MicrobialGA,
  title={Microbial genomics and novel antibiotic discovery: new technology to search for new drugs.},
  author={Thomas J. Dougherty and John F. Barrett and Michael J. Pucci},
  journal={Current pharmaceutical design},
  year={2002},
  volume={8 13},
  pages={
          1119-35
        }
}
The process of prokaryotic drug discovery has been a model of success for over fifty years, yet the number of exploited bacterial targets is a mere fraction, less than 0.1% of the potential targets (based on total number of bacterial genes identified by gene sequence projects). To better understand the potential for drug intervention, multiple paradigms have been established in the pharmaceutical industry, all with some semblance of commonality and uniqueness to provide proprietary positioning… CONTINUE READING

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