Microbial genomic analysis reveals the essential role of inflammation in bacteria-induced colorectal cancer

@inproceedings{Arthur2014MicrobialGA,
  title={Microbial genomic analysis reveals the essential role of inflammation in bacteria-induced colorectal cancer},
  author={Janelle C Arthur and Raad Z. Gharaibeh and Marcus M{\"u}hlbauer and Ernesto Perez-Chanona and Joshua M. Uronis and Jonathan McCafferty and Anthony A. Fodor and Christian Jobin},
  booktitle={Nature communications},
  year={2014}
}
Enterobacteria, especially Escherichia coli, are abundant in patients with inflammatory bowel disease or colorectal cancer (CRC). However, it is unclear whether cancer is promoted by inflammation-induced expansion of E. coli and/or changes in expression of specific microbial genes. Here we use longitudinal (2, 12 and 20 weeks) 16S rRNA sequencing of luminal microbiota from ex-germ-free mice to show that inflamed Il10(-/-) mice maintain a higher abundance of Enterobacteriaceae than healthy wild… CONTINUE READING
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