Microbial genetics: Embrace your inhibitions!

  title={Microbial genetics: Embrace your inhibitions!},
  author={Nick Campbell},
  journal={Nature Reviews Genetics},
A thought-provoking new study indicates that inhibiting mutation in the genomes of pathogenic bacteria might be a viable strategy for dealing with the growing problem of antibiotic resistance. Floyd Romesberg and colleagues used resistance to the synthetic antibiotic ciprofloxacin in Escherichia coli as their model system. Ciprofloxacin interferes with topoisomerases such that they introduce double-strand breaks (DSBs) in the DNA, so it is mutations in genes that encode the topoisomerases (for… CONTINUE READING