Microbial dysbiosis in pediatric patients with Crohn's disease.

  title={Microbial dysbiosis in pediatric patients with Crohn's disease.},
  author={Nadeem O Kaakoush and Andrew S Day and Karina D. Huinao and Steven T Leach and Daniel A Lemberg and Scot E. Dowd and Hazel M Mitchell},
  journal={Journal of clinical microbiology},
  volume={50 10},
Microbial dysbiosis has been suggested to be involved in the pathogenesis of Crohn's disease (CD); however, many studies of gut microbial communities have been confounded by environmental and patient-related factors. In this study, the microbial flora of fecal samples from 19 children newly diagnosed with CD and 21 age-matched controls were analyzed using high-throughput sequencing to determine differences in the microbial composition between CD patients and controls. Analysis of the microbial… CONTINUE READING