Microbial comparative pan-genomics using binomial mixture models

  title={Microbial comparative pan-genomics using binomial mixture models},
  author={Lars Gustav Snipen and Trygve Alm\oy and David Wayne Ussery},
  booktitle={BMC Genomics},
The size of the core- and pan-genome of bacterial species is a topic of increasing interest due to the growing number of sequenced prokaryote genomes, many from the same species. Attempts to estimate these quantities have been made, using regression methods or mixture models. We extend the latter approach by using statistical ideas developed for capture-recapture problems in ecology and epidemiology. We estimate core- and pan-genome sizes for 16 different bacterial species. The results reveal a… CONTINUE READING
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