Microbial biotransformations of a synthetic immunomodulating agent, HR325.

  title={Microbial biotransformations of a synthetic immunomodulating agent, HR325.},
  author={Isabelle Lacroix and Jacques Biton and Robert Azerad},
  journal={Bioorganic & medicinal chemistry},
  volume={5 7},
The microbial biotransformation of HR325 [2-cyano-3-cyclopropyl-3-hydroxy-N-(4'-trifluoromethyl-3'-methylphenyl)- propenamide], a synthetic immunomodulating agent, has been investigated in order to be compared with animal metabolism and to prepare some metabolites which are difficult to obtain by chemical methods. Several fungal strains are able to completely metabolize this drug. Mortierella isabellina NRRL 1757 only achieves a benzylic hydroxylation on the aromatic methyl group, affording in… CONTINUE READING

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