Microbial biosynthesis of the anticoagulant precursor 4-hydroxycoumarin.

@article{Lin2013MicrobialBO,
  title={Microbial biosynthesis of the anticoagulant precursor 4-hydroxycoumarin.},
  author={Yuheng Lin and Xiaolin Shen and Qipeng Yuan and Yajun Yan},
  journal={Nature communications},
  year={2013},
  volume={4},
  pages={2603}
}
4-Hydroxycoumarin (4HC) type anticoagulants (for example, warfarin) are known to have a significant role in the treatment of thromboembolic diseases--a leading cause of patient morbidity and mortality worldwide. 4HC serves as an immediate precursor of these synthetic anticoagulants. Although 4HC was initially identified as a naturally occurring product, its biosynthesis has not been fully elucidated. Here we present the design, validation, in vitro diagnosis and optimization of an artificial… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 28 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 53 references

a missing step in the synthesis of umbelliferone in plants

  • Vialart, G. et al. A 2-oxoglutarate-dependent dioxygenase from C2’H
  • Plant J. 70, 460–470
  • 2012

A bacterial platform for fermentative production of plant alkaloids

  • A Nakagawa
  • Nat. Commun
  • 2011

Efficient ‘on water’ organocatalytic protocol for the synthesis of optically pure warfarin anticoagulant

  • M. Rogozinska, A. Adamkiewicz, J. Mlynarski
  • Green. Chem
  • 2011

Similar Papers

Loading similar papers…