Microbial biosynthesis of the anticoagulant precursor 4-hydroxycoumarin.

  title={Microbial biosynthesis of the anticoagulant precursor 4-hydroxycoumarin.},
  author={Yuheng Lin and Xiaolin Shen and Qipeng Yuan and Yajun Yan},
  journal={Nature communications},
4-Hydroxycoumarin (4HC) type anticoagulants (for example, warfarin) are known to have a significant role in the treatment of thromboembolic diseases--a leading cause of patient morbidity and mortality worldwide. 4HC serves as an immediate precursor of these synthetic anticoagulants. Although 4HC was initially identified as a naturally occurring product, its biosynthesis has not been fully elucidated. Here we present the design, validation, in vitro diagnosis and optimization of an artificial… CONTINUE READING


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