Microbial Transformations of Steroids

  title={Microbial Transformations of Steroids},
  author={Alois {\vC}apek and Oldřich Han{\vc} and Milan Tadra},
  booktitle={Biologia Et Industria},
The absolute substrate specificity was found in studying transformations of steroids by the 663 strain ofBeauveria bassiana. The presence of hydroxyl in 17α - position is critical for the direction of transformation. Pregnene steroids are above all hydroxylated in 11α-position. The 11α - derivative originated from 17α - derivatives is the main and end metabolite. Two more mutually independent reactions occur after 11α-hydroxylation of 17α-nonhydroxylated derivatives, splitting of the side chain… 
A novel, versatile D-BCD steroid construction strategy, illustrated by the total syntheses of estrone and desogestrel
Proposed are the total syntheses of the steroids desogestrel and estrone, utilizing a 1,4 addition/alkylation process to install the correct stereochemistry at C8, C13 and C14 in a single-pot