Microbial Respiration and Formate Oxidation as Metabolic Signatures of Inflammation-Associated Dysbiosis.

@article{Hughes2017MicrobialRA,
  title={Microbial Respiration and Formate Oxidation as Metabolic Signatures of Inflammation-Associated Dysbiosis.},
  author={Elizabeth R. Hughes and Maria G. Winter and Breck A Duerkop and Luisella Spiga and Tatiane Furtado de Carvalho and Wenhan Zhu and Caroline C. Gillis and Lisa B{\"u}ttner and Madeline P Smoot and Cassie L. Behrendt and S. N. Cherry and Renato Lima Santos and Lora V Hooper and Sebastian E Winter},
  journal={Cell host & microbe},
  year={2017},
  volume={21 2},
  pages={208-219}
}
Intestinal inflammation is frequently associated with an alteration of the gut microbiota, termed dysbiosis, which is characterized by a reduced abundance of obligate anaerobic bacteria and an expansion of facultative Proteobacteria such as commensal E. coli. The mechanisms enabling the outgrowth of Proteobacteria during inflammation are incompletely understood. Metagenomic sequencing revealed bacterial formate oxidation and aerobic respiration to be overrepresented metabolic pathways in a… CONTINUE READING
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