Microbial Minimalism Genome Reduction in Bacterial Pathogens

@article{Moran2002MicrobialMG,
  title={Microbial Minimalism Genome Reduction in Bacterial Pathogens},
  author={N. Moran},
  journal={Cell},
  year={2002},
  volume={108},
  pages={583-586}
}
  • N. Moran
  • Published 2002
  • Biology, Medicine
  • Cell
When bacterial lineages make the transition from free-living or facultatively parasitic life cycles to permanent associations with hosts, they undergo a major loss of genes and DNA. Complete genome sequences are providing an understanding of how extreme genome reduction affects evolutionary directions and metabolic capabilities of obligate pathogens and symbionts. 

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References

SHOWING 1-10 OF 17 REFERENCES
Intracellular survival strategies of mutualistic and parasitic prokaryotes.
TLDR
The detailed characterization of symbiotic interactions of bacteria with non-mammalian hosts should provide profound insights into the basic mechanisms of bacteria-host interactions and their evolution. Expand
Reductive evolution of resident genomes.
Small, asexual populations are expected to accumulate deleterious substitutions and deletions in an irreversible manner, which in the long-term will lead to mutational meltdown and genome decay.Expand
Genome size reduction through multiple events of gene disintegration in Buchnera APS.
TLDR
The evolution of the endosymbiont Buchnera during its adaptation to intracellular life involved a massive reduction in its genome which arose from multiple events of gene disintegration dispersed over the whole genome. Expand
Deletional bias and the evolution of bacterial genomes.
TLDR
The evidence showing that deletional bias is a major force that shapes bacterial genomes is discussed, in which dramatic reductions in genome size can result not from selection to lose DNA, but from decreased selection to maintain gene functionality. Expand
Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS
TLDR
The results indicate that Buchnera is completely symbiotic and viable only in its limited niche, the bacteriocyte, and indicates complementarity and syntrophy between the host and the symbiont. Expand
A minimal gene set for cellular life derived by comparison of complete bacterial genomes.
  • A. Mushegian, E. Koonin
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1996
TLDR
It is suggested that the remaining 256 genes are close to the minimal gene set that is necessary and sufficient to sustain the existence of a modern-type cell and speculate that the last common ancestor of the three primary kingdoms had an RNA genome. Expand
Global transposon mutagenesis and a minimal Mycoplasma genome.
TLDR
Global transposon mutagenesis was used to identify nonessential genes in an effort to learn whether the naturally occurring gene complement is a true minimal genome under laboratory growth conditions, and suggests that 265 to 350 of the 480 protein-coding genes of M. genitalium are essential under laboratory growing conditions. Expand
Pseudogenes, junk DNA, and the dynamics of Rickettsia genomes.
TLDR
The results suggest that inactivated genetic material in the Rickettsia genomes deteriorates spontaneously due to a mutation bias for deletions and that the noncoding sequences represent DNA in the final stages of this degenerative process. Expand
The genome sequence of Rickettsia prowazekii and the origin of mitochondria
TLDR
The complete genome sequence of the obligate intracellular parasite Rickettsia prowazekii, the causative agent of epidemic typhus, is described, which contains 834 protein-coding genes and is more closely related to mitochondria than is any other microbe studied so far. Expand
How many genes can make a cell: the minimal-gene-set concept.
  • E. Koonin
  • Biology, Medicine
  • Annual review of genomics and human genetics
  • 2000
TLDR
It became clear that only approximately 80 genes of the 250 in the original minimal gene set are represented by orthologs in all life forms, and some of the genes that were included in the first version, based on a limited genome comparison, could be dispensable. Expand
...
1
2
...