Microbial Ecology of the Production Process

  title={Microbial Ecology of the Production Process},
  author={David Payne},
  • D. Payne
  • Published 26 December 2006
  • Environmental Science
4 Citations
Fluid-Screen as a Real Time Dielectrophoretic Method for Universal Microbial Capture
Data generated supports the superiority of the FS method as compared to the established Plate Counting Method (PCM), that is routinely used to detect bacterial contamination in healthcare, pharmacological and food industries.
Microbiological quality of non-sterile pharmaceuticals in Egypt
Evaluated non-sterile pharmaceuticals in Alexandria, Egypt found average microbiological quality of the tested pharmaceuticals used in Alexandria was below the maximum acceptable limit of TAMC and TYMC.
Sources of Microbial Contamination and Risk Profiling
  • Tim Sandle
  • Environmental Science
    Biocontamination Control for Pharmaceuticals and Healthcare
  • 2019
Spore-forming Bacilli and Clostridia in human disease.
This review will focus on the specific diseases caused by spores of the Clostridia and Bacilli, and the role of bacterially produced toxins in the pathophysiology of infection.


Disinfection and Cleansing
[Microbial contamination of twenty drugs of plant origin].
  • J. Favet
  • Biology, Medicine
    Pharmaceutica acta Helvetiae
  • 1992
Twenty drugs of plant origin were analysed in order to determine the microbial contamination level. A light homogenizing method was used to avoid an increase in the antimicrobial capacity of certain
Comparative microbial contamination levels in wet granulation and direct compression methods of tablet production.
The microbial levels of the tablets were influenced by the microbial quality of the starting raw materials, the production environment and the method of production, indicating that the compaction process exert lethal effect on the survival of microorganisms.
Inimical effects of compaction speed on microorganisms in powder systems with dissimilar compaction mechanisms.
Scanning electron micrographs of fractured compacts revealed that particle rearrangement, fragmentation, and deformation significantly influence the "survivor" in brittle material.
Bacteria associated with granular activated carbon particles in drinking water
Data indicate that bacteria attached to carbon fines may be an important mechanism by which microorganisms penetrate treatment barriers and enter potable water supplies.
Microbiological contamination of raw materials for large-volume parenterals
A wide range of raw materials used for the production of large-volume parenterals were tested for their content of bacteria, molds, yeasts, and endotoxins, although some mannitol samples contained relatively high amounts of endotoxin.
Fungal contamination and mycotoxin detection of powdered herbal drugs
Aspergillus and Penicillium species were predominant, but Rhizopus, Mucor, Cladosporium, and Aureobasidium spp.
Pseudomonas aeruginosa in hospital pharmacies.
The environments of hospital pharmacies and the preparations made in these pharmacies were examined for Pseudomonas aeruginosa and in 11 instances strains of Ps aerug inosa from the preparations bore a close resemblance to strains previously found in the pharmacy environments.
Pseudomonas aeruginosa infections associated with use of contaminated medicaments.
Pseudomonas aeruginosa was recovered from three hospital-prepared medicaments being used on the wards; in five the strains recovered bore a close resemblance to strains previously isolated from the contaminated medicaments.
Microbiological study of water-softener resins.
Increased bacterial retention, survival, and multiplication occurred concomitantly with accumulation of organic and inorganic materials and the Ca(++) and Mg(++) cations from the tap water.