Microbial DNA regulates intestinal homeostasis via the AIM 2 inflammasome

@inproceedings{Waliullah2016MicrobialDR,
  title={Microbial DNA regulates intestinal homeostasis via the AIM 2 inflammasome},
  author={Sumyya Waliullah and Melanie S. Harris and Hasan Zaki},
  year={2016}
}
Absent in melanoma 2 (AIM2) is a cytosolic DNA sensor which upon activation assembles a multiprotein complex called the inflammasome. Previous studies have shown that several inflammasome-forming pattern recognition receptors exhibit a protective function against inflammatory bowel disease and colorectal cancer. However, the role of AIM2 in sensing… CONTINUE READING