Microbe sensing, positive feedback loops, and the pathogenesis of inflammatory diseases.

  title={Microbe sensing, positive feedback loops, and the pathogenesis of inflammatory diseases.},
  author={Bruce Beutler},
  journal={Immunological reviews},
  volume={227 1},
The molecular apparatus that protects us against infection can also injure us by causing autoimmune or autoinflammatory disease. It now seems that at times, defects within the sensing arm of innate immunity contribute to diseases of this type. The initiation of an immune response is often microbe dependent and, in many cases, Toll-like receptor (TLR) dependent. Positive feedback loops triggering immune activation may occur when TLR signaling pathways stimulate host cells in an unchecked manner… CONTINUE READING
Highly Influential
This paper has highly influenced 12 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 109 extracted citations

Toll-like receptor polymorphisms, inflammatory and infectious diseases, allergies, and cancer.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research • 2013
View 8 Excerpts
Highly Influenced

Toll-like receptors in pregnancy disorders and placental dysfunction.

Clinical reviews in allergy & immunology • 2010
View 12 Excerpts
Highly Influenced

Hepatocyte death: a clear and present danger.

View 11 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…