Microbe sensing, positive feedback loops, and the pathogenesis of inflammatory diseases.

@article{Beutler2009MicrobeSP,
  title={Microbe sensing, positive feedback loops, and the pathogenesis of inflammatory diseases.},
  author={Bruce Beutler},
  journal={Immunological reviews},
  year={2009},
  volume={227 1},
  pages={248-63}
}
The molecular apparatus that protects us against infection can also injure us by causing autoimmune or autoinflammatory disease. It now seems that at times, defects within the sensing arm of innate immunity contribute to diseases of this type. The initiation of an immune response is often microbe dependent and, in many cases, Toll-like receptor (TLR) dependent. Positive feedback loops triggering immune activation may occur when TLR signaling pathways stimulate host cells in an unchecked manner… CONTINUE READING
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