Microbe-dependent CD11b+ IgA+ plasma cells mediate robust early-phase intestinal IgA responses in mice

  title={Microbe-dependent CD11b+ IgA+ plasma cells mediate robust early-phase intestinal IgA responses in mice},
  author={Jun Kunisawa and Masashi Gohda and Eri Hashimoto and Izumi Ishikawa and Morio Higuchi and Yuji Suzuki and Yoshiyuki Goto and Casandra Panea and Ivaylo I. Ivanov and Risa Sumiya and Lamichhane Aayam and Taichi Wake and So Tajiri and Yosuke Kurashima and Shiori Shikata and Shizuo Akira and Kiyoshi Takeda and Hiroshi Kiyono},
  booktitle={Nature communications},
Intestinal plasma cells predominantly produce immunoglobulin (Ig) A, however, their functional diversity remains poorly characterized. Here we show that murine intestinal IgA plasma cells can be newly classified into two populations on the basis of CD11b expression, which cannot be discriminated by currently known criteria such as general plasma cell markers, B cell origin and T cell dependence. CD11b(+) IgA(+) plasma cells require the lymphoid structure of Peyer's patches, produce more IgA… CONTINUE READING
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Microarray data have been deposited in the National Center for Biotechnology Information Gene Expression Omnibus database under series accession code GSE37225

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The sensing of environmental stimuli by follicular dendritic cells promotes immunoglobulin A generation in the gut

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