Microarrays of cells expressing defined cDNAs

@article{Ziauddin2001MicroarraysOC,
  title={Microarrays of cells expressing defined cDNAs},
  author={Junaid Ziauddin and David M. Sabatini},
  journal={Nature},
  year={2001},
  volume={411},
  pages={107-110}
}
Genome and expressed sequence tag projects are rapidly cataloguing and cloning the genes of higher organisms, including humans. An emerging challenge is to rapidly uncover the functions of genes and to identify gene products with desired properties. We have developed a microarray-driven gene expression system for the functional analysis of many gene products in parallel. Mammalian cells are cultured on a glass slide printed in defined locations with different DNAs. Cells growing on the printed… CONTINUE READING
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