Microarray profile of differentially expressed genes in a monkey model of allergic asthma

@article{Zou2001MicroarrayPO,
  title={Microarray profile of differentially expressed genes in a monkey model of allergic asthma},
  author={Jun Zou and Simon S. Young and Feng Zhu and Ferdous Gheyas and Susan M Skeans and Yuen Wan and Luquan Wang and Wei Ding and M. Motasim Billah and Terri Mcclanahan and Robert Lee Coffman and Robert W. Egan and Shelby P. Umland},
  journal={Genome Biology},
  year={2001},
  volume={3},
  pages={research0020.1 - research0020.13}
}
Inhalation of Ascaris suum antigen by allergic monkeys causes an immediate bronchoconstriction and delayed allergic reaction, including a pulmonary inflammatory infiltrate. To identify genes involved in this process, the gene-expression pattern of allergic monkey lungs was profiled by microarrays. Monkeys were challenged by inhalation of A. suum antigen or given interleukin-4 (IL-4) treatment; lung tissue was collected at 4, 18 or 24 h after antigen challenge or 24 h after IL-4. Each challenged… CONTINUE READING