Microarray identifies extensive downregulation of noncollagen extracellular matrix and profibrotic growth factor genes in chronic isolated mitral regurgitation in the dog.

@article{Zheng2009MicroarrayIE,
  title={Microarray identifies extensive downregulation of noncollagen extracellular matrix and profibrotic growth factor genes in chronic isolated mitral regurgitation in the dog.},
  author={Junying Zheng and Yuanwen Chen and Betty M Pat and Louis Dell'italia and Michael Tillson and A. Ray Dillon and Pamela C. Powell and Ke Shi and Neil R. Shah and Thomas S. Denney and Ahsan Husain and Louis J. Dell'Italia},
  journal={Circulation},
  year={2009},
  volume={119 15},
  pages={
          2086-95
        }
}
BACKGROUND The volume overload of isolated mitral regurgitation (MR) in the dog results in left ventricular (LV) dilatation and interstitial collagen loss. To better understand the mechanism of collagen loss, we performed a gene array and overlaid regulated genes into ingenuity pathway analysis. METHODS AND RESULTS Gene arrays from LV tissue were compared in 4 dogs before and 4 months after MR. Cine-magnetic resonance-derived LV end-diastolic volume increased 2-fold (P=0.005), and LV ejection… CONTINUE READING

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  • Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology
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  • 2019
VIEW 3 EXCERPTS
CITES BACKGROUND