Microarray gene expression analysis of murine tumor heterogeneity defined by dynamic contrast-enhanced MRI.

@article{Costouros2002MicroarrayGE,
  title={Microarray gene expression analysis of murine tumor heterogeneity defined by dynamic contrast-enhanced MRI.},
  author={Nick G Costouros and Dominique Lorang and Yantian Zhang and Marshall S Miller and Felix E Diehn and Stephen M. Hewitt and Michael V. Knopp and King Chuen Li and Peter L. Choyke and H. Richard Alexander and Steven K. Libutti},
  journal={Molecular imaging},
  year={2002},
  volume={1 3},
  pages={301-8}
}
Current methods of studying angiogenesis are limited in their ability to serially evaluate in vivo function throughout a target tissue. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and pharmacokinetic modeling provide a useful method for evaluating tissue vasculature based on contrast accumulation and washout. While it is often assumed that areas of high contrast enhancement and washout comprise areas of increased angiogenesis and tumor activity, the actual molecular pathways… CONTINUE READING