Microarray expression analysis of gad mice implicates involvement of Parkinson's disease associated UCH-L1 in multiple metabolic pathways.

@article{Bonin2004MicroarrayEA,
  title={Microarray expression analysis of gad mice implicates involvement of Parkinson's disease associated UCH-L1 in multiple metabolic pathways.},
  author={Michael Bonin and Sven Poths and Hitoshi Osaka and Yuliang Wang and Ken Wada and Olaf Riess},
  journal={Brain research. Molecular brain research},
  year={2004},
  volume={126 1},
  pages={88-97}
}
Parkinson's disease (PD) is thought to be caused by environmental and genetic factors. Mutations in four genes, alpha-synuclein, parkin, DJ-1, and UCH-L1, have been identified in autosomal inherited forms of PD. The pathogenetic cause for the loss of neuronal cells in PD patients, however, remains to be determined. Due to the rarity of mutations in humans with PD, the analysis of animal models might help to further gain insights into the pathogenesis of familial PD. For UCH-L1, deficiency has… CONTINUE READING

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