Microarray and real-time PCR analysis of adrenal gland gene expression in the 7-day-old rat: effects of hypoxia from birth.

@article{Bruder2007MicroarrayAR,
  title={Microarray and real-time PCR analysis of adrenal gland gene expression in the 7-day-old rat: effects of hypoxia from birth.},
  author={Eric D. Bruder and Julie J Lee and Eric P. Widmaier and Hershel Raff},
  journal={Physiological genomics},
  year={2007},
  volume={29 2},
  pages={193-200}
}
We hypothesize that changes in adrenal gene expression mediate the increased plasma corticosterone and steroidogenesis in rat pups exposed to hypoxia from birth. In the current study, rat pups (with their dams) were exposed to hypoxia from birth and compared with pups from normoxic dams fed ad libitum or pair fed to match the decreased maternal food intake that occurs during hypoxia. Microarray analysis was performed, followed by verification with real-time PCR. Furthermore, the expression of… CONTINUE READING