Microarray analysis unmasked two siblings with pure hereditary spastic paraplegia shared a run of homozygosity region on chromosome 3q28-q29.

@article{Yu2015MicroarrayAU,
  title={Microarray analysis unmasked two siblings with pure hereditary spastic paraplegia shared a run of homozygosity region on chromosome 3q28-q29.},
  author={Wenqian Yu and Xiangdong You and Dong Wang and Kai Dong and Jing Su and Chuanfen Li and Jinxiu Liu and Qianqian Zhang and Feng You and Xiangrong Wang and Jing Huang and Bin Qiao and Wenyuan Duan},
  journal={Journal of the neurological sciences},
  year={2015},
  volume={359 1-2},
  pages={351-5}
}
Hereditary spastic paraplegia (HSP) is a clinical and genetic heterogeneity group of neurodegenerative disorders which is characterized by progressive weakness and spasticity of the lower limbs. More than 70 genetic types of HSP have been described so far. Here we describe a Chinese non-consanguineous family with two affected siblings manifesting early… CONTINUE READING