Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs

  title={Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs},
  author={L. Lim and N. Lau and P. Garrett-engele and A. Grimson and J. Schelter and J. Castle and D. Bartel and P. Linsley and J. Johnson},
  • L. Lim, N. Lau, +6 authors J. Johnson
  • Published 2005
  • Biology, Medicine
  • Nature
  • MicroRNAs (miRNAs) are a class of noncoding RNAs that post-transcriptionally regulate gene expression in plants and animals. To investigate the influence of miRNAs on transcript levels, we transfected miRNAs into human cells and used microarrays to examine changes in the messenger RNA profile. Here we show that delivering miR-124 causes the expression profile to shift towards that of brain, the organ in which miR-124 is preferentially expressed, whereas delivering miR-1 shifts the profile… CONTINUE READING

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