Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs

@article{Lim2005MicroarrayAS,
  title={Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs},
  author={Lee P. Lim and Nelson C. Lau and Philip W. Garrett-engele and Andrew Grimson and Janell M. Schelter and John C. Castle and David P. Bartel and Peter S. Linsley and Jason M. Johnson},
  journal={Nature},
  year={2005},
  volume={433},
  pages={769-773}
}
MicroRNAs (miRNAs) are a class of noncoding RNAs that post-transcriptionally regulate gene expression in plants and animals. To investigate the influence of miRNAs on transcript levels, we transfected miRNAs into human cells and used microarrays to examine changes in the messenger RNA profile. Here we show that delivering miR-124 causes the expression profile to shift towards that of brain, the organ in which miR-124 is preferentially expressed, whereas delivering miR-1 shifts the profile… Expand
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