Microarray analysis of temporal gene responses to ionizing radiation in two glioblastoma cell lines: up-regulation of DNA repair genes.

@article{Otomo2004MicroarrayAO,
  title={Microarray analysis of temporal gene responses to ionizing radiation in two glioblastoma cell lines: up-regulation of DNA repair genes.},
  author={Takashi Otomo and Makoto Hishii and Hajime Arai and Kiyoshi Sato and Keisuke Sasai},
  journal={Journal of radiation research},
  year={2004},
  volume={45 1},
  pages={53-60}
}
To determine the patterns of gene expression responsible for the radiosensitivity of glioblastoma cells, we analyzed transcriptional changes after ionizing radiation in different cell lines. After completing clonogenic survival assays, we selected two glioblastoma cell lines with different radiosensitivities. Subsequently, they were investigated by using the technique of DNA microarray, and we then categorized the upregulated genes into 10 groups. Between the two cell lines, the difference in… CONTINUE READING