Microarray analysis of retinal endothelial tip cells identifies CXCR4 as a mediator of tip cell morphology and branching.

@article{Strasser2010MicroarrayAO,
  title={Microarray analysis of retinal endothelial tip cells identifies CXCR4 as a mediator of tip cell morphology and branching.},
  author={Geraldine A. Strasser and Joshua S. Kaminker and Marc Tessier-Lavigne},
  journal={Blood},
  year={2010},
  volume={115 24},
  pages={5102-10}
}
The development of the vertebrate vascular system is mediated by both genetic patterning of vessels and by angiogenic sprouting in response to hypoxia. Both of these processes depend on the detection of environmental guidance cues by endothelial cells. A specialized subtype of endothelial cell known as the tip cell is thought to be involved in the detection and response to these cues, but the molecular signaling pathways used by tip cells to mediate tissue vascularization remain largely… CONTINUE READING