Microarray analysis of in vitro pericyte differentiation reveals an angiogenic program of gene expression.

@article{Kale2005MicroarrayAO,
  title={Microarray analysis of in vitro pericyte differentiation reveals an angiogenic program of gene expression.},
  author={Sujata Kale and Jun-ichi Hanai and Barden Chan and Anil Karihaloo and Gary Grotendorst and Lloyd Cantley and Vikas P Sukhatme},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2005},
  volume={19 2},
  pages={270-1}
}
The vasculature consists of endothelial cells (ECs) lined by pericyte/vascular smooth muscle cells (vSMCs). Pericyte/vSMCs provide support to the mature vasculature but are also essential for normal blood vessel development. To determine how pericyte-EC communication influences vascular development, we used the well-established in vitro model of TGFbeta-stimulated differentiation of 10T1/2 cells into pericyte/vSMCs. Microarray analysis was performed to identify genes that were differentially… CONTINUE READING
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