Microarray analysis of differential gene expression in androgen independent prostate cancer using a metastatic human prostate cancer cell line model.

@article{Balaji2004MicroarrayAO,
  title={Microarray analysis of differential gene expression in androgen independent prostate cancer using a metastatic human prostate cancer cell line model.},
  author={Kethandapatti C. Balaji and P Syamasundar Rao and David J. Smith and Somaja Louis and Lynette M. Smith and Simon Sherman and Dean John Bacich and Denise S. O'Keefe},
  journal={Urologic oncology},
  year={2004},
  volume={22 4},
  pages={313-20}
}
Progression to androgen independence (AI) leading to uncontrolled cell growth is the main cause of death in prostate cancer. While almost all patients with metastatic prostate cancer will initially respond to anti-androgen treatments, the majority will fail hormonal treatments in less than 2 yrs. Both genetic and epigenetic alterations in gene expression contribute significantly to the development of AI. To investigate this we have used an in vitro cell line model of AI prostate cancer from… CONTINUE READING