Microarray analysis of changes in bone cell gene expression early after cadmium gavage in mice.

@article{Regunathan2003MicroarrayAO,
  title={Microarray analysis of changes in bone cell gene expression early after cadmium gavage in mice.},
  author={Akhila Regunathan and David A Glesne and Allison K. Wilson and Jongwoo Song and Dan L. Nicolae and Tony Flores and Maryka H. Bhattacharyya},
  journal={Toxicology and applied pharmacology},
  year={2003},
  volume={191 3},
  pages={272-93}
}
We developed an in vivo model for cadmium-induced bone loss in which mice excrete bone mineral in feces beginning 8 h after cadmium gavage. Female mice of three strains [CF1, MTN (metallothionein-wild-type), and MT1,2KO (MT1,2-deficient)] were placed on a low-calcium diet for 2 weeks. Each mouse was gavaged with 200 microg Cd or vehicle only. Fecal calcium was monitored daily for 9 days, beginning 4 days before cadmium gavage, to document the bone response. For CF1 mice, bones were taken from… CONTINUE READING