Microarray analysis of Tbx2-directed gene expression: a possible role in osteogenesis.

@article{Chen2001MicroarrayAO,
  title={Microarray analysis of Tbx2-directed gene expression: a possible role in osteogenesis.},
  author={Jianguang Chen and Qing Zhong and Jun Wang and Richard Cameron and James L. Borke and Carlos M. Isales and Roni J. Bollag},
  journal={Molecular and cellular endocrinology},
  year={2001},
  volume={177 1-2},
  pages={43-54}
}
Tbx2 is a member of the developmentally important transcriptional regulatory T-box gene family, whose target genes have not been well characterized. In an attempt to identify genes that may be regulated by Tbx2, mouse cDNA microarrays were used to analyze differential gene expression profiles, comparing stably transfected NIH3T3 cells overexpressing Tbx2 and vector-transfected controls. Among 8734 genes, 107 genes were up-regulated by 2-fold or greater, and 66 genes were down-regulated by 2… CONTINUE READING
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