Microarray analysis in B cells among siblings with/without MS - role for transcription factor TCF2

@article{Avasarala2007MicroarrayAI,
  title={Microarray analysis in B cells among siblings with/without MS - role for transcription factor TCF2},
  author={Jagannadha R. Avasarala and Sridar V. Chittur and Ajish George and John A Tine},
  journal={BMC Medical Genomics},
  year={2007},
  volume={1},
  pages={2 - 2}
}
We investigated if global gene expression and transcription networks in B-lymphocytes of siblings with multiple sclerosis (MS) were different from healthy siblings. Using virus-transformed immortalized B cells and human whole genome bioarrays with validation using RT-qPCR, we found that in siblings with MS, genes for CXCL10, serpin B1 and FUT4 were up regulated whereas CDC5L, TNFRSF19 and HLA-DR were down regulated, among others; transcription analysis showed two intersecting clusters of… CONTINUE READING

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