Microarray analysis identifies genes preferentially expressed in the lung schistosomulum of Schistosoma mansoni.

@article{Dillon2006MicroarrayAI,
  title={Microarray analysis identifies genes preferentially expressed in the lung schistosomulum of Schistosoma mansoni.},
  author={Gary P. Dillon and Theresa Feltwell and Jason P Skelton and Peter D. Ashton and Patricia S. Coulson and Michael A. Quail and Nefeli Nikolaidou-Katsaridou and R Alan Wilson and Alasdair C. Ivens},
  journal={International journal for parasitology},
  year={2006},
  volume={36 1},
  pages={1-8}
}
The lung schistosomulum of Schistosoma mansoni is a validated target of protective immunity elicited in vaccinated mice. To identify genes expressed at this stage we constructed a microarray, representing 3088 contigs and singlets, with cDNA derived from in vitro cultured larvae and used it to screen RNA from seven life-cycle stages. Clustering of genes by expression profile across the life cycle revealed a number of membrane, membrane-associated and secreted proteins up-regulated at the lung… CONTINUE READING

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