Microarray analyses of the metabolic responses of Saccharomyces cerevisiae to organic solvent dimethyl sulfoxide

@article{Zhang2003MicroarrayAO,
  title={Microarray analyses of the metabolic responses of Saccharomyces cerevisiae to organic solvent dimethyl sulfoxide},
  author={Weiwen Zhang and David L. Needham and Marie Coffin and April Rooker and Patrick Hurban and Matthew M. Tanzer and Jeffrey R. Shuster},
  journal={Journal of Industrial Microbiology and Biotechnology},
  year={2003},
  volume={30},
  pages={57-69}
}
The toxic effects that organic solvents have on whole cells are important drawbacks in the application of these solvents in the production of fine chemicals by whole-cell stereoselective biotransformations. Although early studies found that organic solvents mainly destroyed the integrity of cell membranes by accumulating in the lipid bilayer of plasma membranes, the cellular metabolic responses to the presence of an organic solvent remain unclear. With the rapid development of genomics, it is… CONTINUE READING

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