Microarray Glycoprofiling of CA125 improves differential diagnosis of ovarian cancer.

@article{Chen2013MicroarrayGO,
  title={Microarray Glycoprofiling of CA125 improves differential diagnosis of ovarian cancer.},
  author={Kowa Chen and Aleksandra Gentry-Maharaj and Matthew Grant Burnell and Catharina Steentoft and Lara Marcos-Silva and Ulla Mandel and Ian Jacobs and Anne Dawnay and Christine Rebischung and Ola Blixt},
  journal={Journal of proteome research},
  year={2013},
  volume={12 3},
  pages={
          1408-18
        }
}
The CA125 biomarker assay plays an important role in the diagnosis and management of primary invasive epithelial ovarian/tubal cancer (iEOC). However, a fundamental problem with CA125 is that it is not cancer-specific and may be elevated in benign gynecological conditions such as benign ovarian neoplasms and endometriosis. Aberrant O-glycosylation is an inherent and specific property of cancer cells and could potentially aid in differentiating cancer from these benign conditions, thereby… CONTINUE READING
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