Microarray-Based Analysis of Methylation of 1st Trimester Trisomic Placentas from Down Syndrome, Edwards Syndrome and Patau Syndrome

@article{Hatt2016MicroarrayBasedAO,
  title={Microarray-Based Analysis of Methylation of 1st Trimester Trisomic Placentas from Down Syndrome, Edwards Syndrome and Patau Syndrome},
  author={L. Hatt and M. M. Aagaard and C. Bach and Jesper Graakjaer and S. Sommer and I. Agerholm and S. Kolvraa and A. Bojesen},
  journal={PLoS ONE},
  year={2016},
  volume={11}
}
  • L. Hatt, M. M. Aagaard, +5 authors A. Bojesen
  • Published 2016
  • Biology, Medicine
  • PLoS ONE
  • Methylation-based non-invasive prenatal testing of fetal aneuploidies is an alternative method that could possibly improve fetal aneuploidy diagnosis, especially for trisomy 13(T13) and trisomy 18(T18). Our aim was to study the methylation landscape in placenta DNA from trisomy 13, 18 and 21 pregnancies in an attempt to find trisomy–specific methylation differences better suited for non-invasive prenatal diagnosis. We have conducted high-resolution methylation specific bead chip microarray… CONTINUE READING
    10 Citations

    Figures, Tables, and Topics from this paper.

    LINE-1 retrotransposon methylation in chorionic villi of first trimester miscarriages with aneuploidy
    Global impacts of chromosomal imbalance on gene expression in Arabidopsis and other taxa
    • 16
    • PDF
    Down Syndrome, Ageing and Epigenetics.
    • 1

    References

    SHOWING 1-10 OF 15 REFERENCES
    DNA-Methylation Profiling of Fetal Tissues Reveals Marked Epigenetic Differences between Chorionic and Amniotic Samples
    • 29
    • PDF
    Identification of trisomy 18, trisomy 13, and Down syndrome from maternal plasma
    • 17
    • PDF
    Altered DNA Methylation in Leukocytes with Trisomy 21
    • 89
    • PDF
    Global DNA Hypermethylation in Down Syndrome Placenta
    • 69
    • Highly Influential
    • PDF
    The human placenta methylome
    • 198
    • PDF