Microarray Analysis of the Global Alterations in the Gene Expression in the Placentas From Cigarette‐smoking Mothers

@article{Huuskonen2008MicroarrayAO,
  title={Microarray Analysis of the Global Alterations in the Gene Expression in the Placentas From Cigarette‐smoking Mothers},
  author={P. Huuskonen and M. Storvik and M. Reinisalo and P. Honkakoski and J. Rys{\"a} and J. Hakkola and M. Pasanen},
  journal={Clinical Pharmacology \& Therapeutics},
  year={2008},
  volume={83}
}
The effects of maternal cigarette smoking on the transcriptome of human full‐term placentas were investigated by a microarray analysis. QPCR was performed for a selected set of metabolizing genes. Differentially expressed genes were selected by fold change (±1.5‐fold) and analysis of variance (P<0.05) between the control and smoker groups. The expression of 174 probe sets was affected significantly. Chronic cigarette smoking induced the expression of CYP1A1. A trend toward a decrease in the… Expand
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