Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells

@inproceedings{Xiong2017MicroarrayAO,
  title={Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells},
  author={Wei Xiong and Yi-Qin Ai and Yun-Fen Li and Qing Ye and Zheng-Ting Chen and Ji-Yong Qin and Qiu-Yan Liu and Hong X. Wang and Yun-He Ju and Wenhui Li and Yun-Feng Li},
  booktitle={BioMed research international},
  year={2017}
}
Preoperative 5-fluorouracil- (5-FU-) based chemoradiotherapy is a standard treatment for locally advanced colorectal cancer (CRC). However, the effect of 5-FU-based chemoradiotherapy on CRC is limited due to the development of chemoradiation resistance (CRR), and the molecular mechanisms underlying this resistance are yet to be investigated. Recently, circular RNAs (circRNAs), which can function as microRNA sponges, were found to be involved in the development of several cancers. In this study… CONTINUE READING

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