Microanatomical correlates of cognitive ability and decline: normal ageing, MCI, and Alzheimer's disease.

@article{Chance2011MicroanatomicalCO,
  title={Microanatomical correlates of cognitive ability and decline: normal ageing, MCI, and Alzheimer's disease.},
  author={Steven A. Chance and Linda M. Clover and Helena Cousijn and Leila Currah and Rosemary Pettingill and Margaret M. Esiri},
  journal={Cerebral cortex},
  year={2011},
  volume={21 8},
  pages={1870-8}
}
Few microanatomical measures have been reliably correlated with cognitive measures in aging and Alzheimer's disease (AD), particularly in the early stages of degeneration, such as mild cognitive impairment (MCI). However, cortical minicolumn organization has been shown to correlate with cognitive ability in aging monkeys, and the present study extends this finding to humans. We have previously reported that minicolumn spacing of cells in human association cortex is selectively reduced in normal… CONTINUE READING