Microanalysis of melanins in mammalian hair by alkaline hydrogen peroxide degradation: identification of a new structural marker of pheomelanins.

@article{Napolitano2000MicroanalysisOM,
  title={Microanalysis of melanins in mammalian hair by alkaline hydrogen peroxide degradation: identification of a new structural marker of pheomelanins.},
  author={Alessandra Napolitano and M R Vincensi and Paola Di Donato and Giuseppe Monfrecola and Giuseppe Prota},
  journal={The Journal of investigative dermatology},
  year={2000},
  volume={114 6},
  pages={1141-7}
}
A highly sensitive, easy-to-perform method for melanin analysis in pigmented tissues based on alkaline hydrogen peroxide degradation has been developed and accomplishes simultaneous determination of eumelanins and pheomelanins. Pyrrole-2,3,5- tricarboxylic acid, the typical eumelanin marker, was obtained in higher yields than in previous procedures. A benzothiazole acid, 6-(2-amino-2-carboxyethyl)-2-carboxy-4-hydroxybenzothiazole, characterized in our previous studies as a specific marker of… CONTINUE READING

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