MicroSCALE screening reveals genetic modifiers of therapeutic response in melanoma.

@article{Wood2012MicroSCALESR,
  title={MicroSCALE screening reveals genetic modifiers of therapeutic response in melanoma.},
  author={Kris C. Wood and David J. Konieczkowski and Cory M. Johannessen and Jesse S Boehm and Pablo Tamayo and Olga B. Botvinnik and Jill P. Mesirov and William C. Hahn and David E Root and Levi A. Garraway and David M. Sabatini},
  journal={Science signaling},
  year={2012},
  volume={5 224},
  pages={rs4}
}
Cell microarrays are a promising tool for performing large-scale functional genomic screening in mammalian cells at reasonable cost, but owing to technical limitations they have been restricted for use with a narrow range of cell lines and short-term assays. Here, we describe MicroSCALE (Microarrays of Spatially Confined Adhesive Lentiviral Features), a cell microarray-based platform that enables application of this technology to a wide range of cell types and longer-term assays. We used… CONTINUE READING