MicroRNAs suggest a new mechanism for altered brain gene expression in schizophrenia.

@article{Coyle2009MicroRNAsSA,
  title={MicroRNAs suggest a new mechanism for altered brain gene expression in schizophrenia.},
  author={Joseph T Coyle},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 9},
  pages={
          2975-6
        }
}
N europharmacologic and genetic association studies implicate dysregulation of NMDA receptor function in the pathophysiology of schizophrenia and bipolar disorder (1). In this issue of PNAS Kocerha et al. (2) suggest a novel molecular mechanism whereby a microRNA (miRNA) regulates signaling downstream from the NMDA receptor at the calcium/ calmodulin-dependent protein kinase II subunit (CaMKII ). They found that acute treatment of mice with the potent NMDA receptor antagonist dizocilpine… CONTINUE READING

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Glutamateandschizophrenia : Beyondthe dopamine hypothesis

  • J Kocerha
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