MicroRNAs shape circadian hepatic gene expression on a transcriptome-wide scale

@inproceedings{Du2014MicroRNAsSC,
  title={MicroRNAs shape circadian hepatic gene expression on a transcriptome-wide scale},
  author={N Du and Alaaddin Bulak Arpat and Mara De Matos and David Gatfield},
  booktitle={eLife},
  year={2014}
}
A considerable proportion of mammalian gene expression undergoes circadian oscillations. Post-transcriptional mechanisms likely make important contributions to mRNA abundance rhythms. We have investigated how microRNAs (miRNAs) contribute to core clock and clock-controlled gene expression using mice in which miRNA biogenesis can be inactivated in the liver. While the hepatic core clock was surprisingly resilient to miRNA loss, whole transcriptome sequencing uncovered widespread effects on clock… CONTINUE READING
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Data from: MicroRNAs shape circadian hepatic gene expression on a transcriptome-wide scale

  • NH Du, AB Arpat, M De Matos, D. Gatfield
  • Dryad Digital Repository. doi: 10.5061/dryad…
  • 2014
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