MicroRNAs regulate ocular neovascularization.

  title={MicroRNAs regulate ocular neovascularization.},
  author={Jikui Shen and Xiaoru Yang and Bing Xie and Yangjian Chen and Mara E Swaim and Sean Francis Hackett and Peter Anthony Campochiaro},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  volume={16 7},
In this study, we used ischemia-induced retinal neovascularization (NV) as a model to investigate the possible role of microRNAs in a clinically important disease process. Microarray analysis demonstrated seven microRNAs (miR-106a, -146, -181, -199a, -214, -424, and -451) that were substantially increased and three microRNAs (miR-31, -150, and -184) that were substantially decreased in ischemic retina. Potential targets for the upregulated microRNAs were not identified, but bioinformatic… CONTINUE READING
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