MicroRNAs regulate KDM5 histone demethylases in breast cancer cells.

@article{Denis2016MicroRNAsRK,
  title={MicroRNAs regulate KDM5 histone demethylases in breast cancer cells.},
  author={H{\'e}l{\`e}ne Denis and Olivier Van Grembergen and Benjamin Delatte and Sarah Dedeurwaerder and Pascale Putmans and Emilie Calonne and Françoise Roth{\'e} and Christos P. Sotiriou and François Fuks and Rachel Deplus},
  journal={Molecular bioSystems},
  year={2016},
  volume={12 2},
  pages={
          404-13
        }
}
MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate gene expression. Alteration of miRNA levels is common in tumors and contributes to the pathogenesis of human malignancies. In the present study we examined the role played by miR-137 in breast tumorigenesis. We found miR-137 levels to be lower in breast cancer cells than in their non-tumorigenic counterparts and observed reduced proliferation and migration of breast cancer cells overexpressing miR-137. We further… CONTINUE READING
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