MicroRNAs modulate the chemosensitivity of tumor cells.

  title={MicroRNAs modulate the chemosensitivity of tumor cells.},
  author={Paul E. Blower and J Chung and Joseph S. Verducci and Shili Lin and Jong-Kook Park and Zunyan Dai and C Liu and Thomas D. Schmittgen and William C. Reinhold and Carlo M. Croce and John N. Weinstein and Wolfgang Sadee},
  journal={Molecular cancer therapeutics},
  volume={7 1},
MicroRNAs are strongly implicated in such processes as development, carcinogenesis, cell survival, and apoptosis. It is likely, therefore, that they can also modulate sensitivity and resistance to anticancer drugs in substantial ways. To test this hypothesis, we studied the pharmacologic roles of three microRNAs previously implicated in cancer biology (let-7i, mir-16, and mir-21) and also used in silico methods to test pharmacologic microRNA effects more broadly. In the experimental system, we… CONTINUE READING