MicroRNAs miR-26a, miR-26b, and miR-29b accelerate osteogenic differentiation of unrestricted somatic stem cells from human cord blood

@inproceedings{Trompeter2012MicroRNAsMM,
  title={MicroRNAs miR-26a, miR-26b, and miR-29b accelerate osteogenic differentiation of unrestricted somatic stem cells from human cord blood},
  author={Hans-Ingo Trompeter and Janine D. Dreesen and Eugenie Hermann and Katharina M. Iwaniuk and Markus Hafner and Neil Renwick and Thomas Tuschl and Peter Wernet},
  booktitle={BMC Genomics},
  year={2012}
}
MicroRNAs are a population of short non-coding RNAs with widespread negative regulatory impact on mRNA translation. Unrestricted somatic stem cells (USSC) are a rare population in human cord blood that can be induced into cells representative of all three germinal layers. Here we analyzed the functional impact of miRNAs on the osteogenic differentiation in USSC. Gene expression profiling identified 20 microRNAs that were consistently upregulated during osteogenic differentiation of two… CONTINUE READING
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