MicroRNAs miR-125a and miR-125b constitutively activate the NF-κB pathway by targeting the tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20).

@article{Kim2012MicroRNAsMA,
  title={MicroRNAs miR-125a and miR-125b constitutively activate the NF-κB pathway by targeting the tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20).},
  author={S Kim and Kumaraguruparan Ramasamy and Hakim Bouamar and A W Lin and Daifeng Jiang and Ricardo Aguiar},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 20},
  pages={7865-70}
}
Constitutive activation of the NF-κB pathway is associated with diffuse large B-cell lymphoma (DLBCL) pathogenesis, but whether microRNA dysfunction can contribute to these events remains unclear. Starting from an integrative screening strategy, we uncovered that the negative NF-κB regulator TNFAIP3 is a direct target of miR-125a and miR-125b, which are commonly gained and/or overexpressed in DLBCL. Ectopic expression of these microRNAs in multiple cell models enhanced K63-linked ubiquitination… CONTINUE READING
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