MicroRNAs involved in the regulation of postischemic cardiac fibrosis.

@article{Dai2013MicroRNAsII,
  title={MicroRNAs involved in the regulation of postischemic cardiac fibrosis.},
  author={Yao Dai and Magomed Khaidakov and Xianwei Wang and Zufeng Ding and Wei Su and Elvin T Price and Philip Palade and Ming-wei Chen and Jawahar Lal Mehta},
  journal={Hypertension},
  year={2013},
  volume={61 4},
  pages={751-6}
}
A s deaths from acute myocardial infarction have declined dramatically over the past several decades, more and more patients survive with chronic myocardial ischemia. Hearts of most patients who survive acute myocardial infarction undergo remodeling. Hearts of most patients with sustained hyperten-sion, another common cardiovascular disease, also show some degree of remodeling. The heart consists of 3 primary cell types: cardiomyocytes, fibroblasts, and endothelial cells. Myocytes occupy 75% of… CONTINUE READING

Connections & Topics

Mentioned Connections BETA
Fibrosis during chronic ischemia and sustained hyperten - sion occurs not only in the heart but also in distant organs , such as lung , liver , kidney , pancreas , spleen , nervous system , and bone marrow .
CollagenNo subtypeElastin
Fibroblasts are primarily responsible for the maintenance of extracellular matrix ( ECM ) that is composed of collagens , fibronectins , elastins , fibrillins , and several other proteins .
ElastinNo subtypeCollagen
Fibroblasts are primarily responsible for the maintenance of extracellular matrix ( ECM ) that is composed of collagens , fibronectins , elastins , fibrillins , and several other proteins .
Fibroblasts are primarily responsible for the maintenance of extracellular matrix ( ECM ) that is composed of collagens , fibronectins , elastins , fibrillins , and several other proteins .
Fibroblasts are primarily responsible for the maintenance of extracellular matrix ( ECM ) that is composed of collagens , fibronectins , elastins , fibrillins , and several other proteins .
Fibroblasts are primarily responsible for the maintenance of extracellular matrix ( ECM ) that is composed of collagens , fibronectins , elastins , fibrillins , and several other proteins .
Fibroblasts are primarily responsible for the maintenance of extracellular matrix ( ECM ) that is composed of collagens , fibronectins , elastins , fibrillins , and several other proteins .
Fibroblasts are primarily responsible for the maintenance of extracellular matrix ( ECM ) that is composed of collagens , fibronectins , elastins , fibrillins , and several other proteins .
Fibroblasts are primarily responsible for the maintenance of extracellular matrix ( ECM ) that is composed of collagens , fibronectins , elastins , fibrillins , and several other proteins .
Fibroblasts are primarily responsible for the maintenance of extracellular matrix ( ECM ) that is composed of collagens , fibronectins , elastins , fibrillins , and several other proteins .
Fibroblasts are primarily responsible for the maintenance of extracellular matrix ( ECM ) that is composed of collagens , fibronectins , elastins , fibrillins , and several other proteins .
Extracellular MatrixIs associated anatomy of gene productCollagen
Fibroblasts are primarily responsible for the maintenance of extracellular matrix ( ECM ) that is composed of collagens , fibronectins , elastins , fibrillins , and several other proteins .
Extracellular MatrixIs associated anatomy of gene productElastin
Fibroblasts are primarily responsible for the maintenance of extracellular matrix ( ECM ) that is composed of collagens , fibronectins , elastins , fibrillins , and several other proteins .
Fibroblasts are primarily responsible for the maintenance of extracellular matrix ( ECM ) that is composed of collagens , fibronectins , elastins , fibrillins , and several other proteins .
Fibroblasts are primarily responsible for the maintenance of extracellular matrix ( ECM ) that is composed of collagens , fibronectins , elastins , fibrillins , and several other proteins .
Fibroblasts are primarily responsible for the maintenance of extracellular matrix ( ECM ) that is composed of collagens , fibronectins , elastins , fibrillins , and several other proteins .
Fibroblasts are primarily responsible for the maintenance of extracellular matrix ( ECM ) that is composed of collagens , fibronectins , elastins , fibrillins , and several other proteins .
These processes , along with inappropriate release of proinflammatory cytokines from endothelial cells , inflam - matory cells , and cardiomyocytes , 8 lead to a state of cardiac dysfunction resulting in the clinical syndrome of heart failure .
These processes , along with inappropriate release of proinflammatory cytokines from endothelial cells , inflam - matory cells , and cardiomyocytes , 8 lead to a state of cardiac dysfunction resulting in the clinical syndrome of heart failure .
These processes , along with inappropriate release of proinflammatory cytokines from endothelial cells , inflam - matory cells , and cardiomyocytes , 8 lead to a state of cardiac dysfunction resulting in the clinical syndrome of heart failure .
These processes , along with inappropriate release of proinflammatory cytokines from endothelial cells , inflam - matory cells , and cardiomyocytes , 8 lead to a state of cardiac dysfunction resulting in the clinical syndrome of heart failure .
These processes , along with inappropriate release of proinflammatory cytokines from endothelial cells , inflam - matory cells , and cardiomyocytes , 8 lead to a state of cardiac dysfunction resulting in the clinical syndrome of heart failure .
These processes , along with inappropriate release of proinflammatory cytokines from endothelial cells , inflam - matory cells , and cardiomyocytes , 8 lead to a state of cardiac dysfunction resulting in the clinical syndrome of heart failure .
These processes , along with inappropriate release of proinflammatory cytokines from endothelial cells , inflam - matory cells , and cardiomyocytes , 8 lead to a state of cardiac dysfunction resulting in the clinical syndrome of heart failure .
A s deaths from acute myocardial infarction have declined dramatically over the past several decades , more and more patients survive with chronic myocardial ischemia .
A s deaths from acute myocardial infarction have declined dramatically over the past several decades , more and more patients survive with chronic myocardial ischemia .
A s deaths from acute myocardial infarction have declined dramatically over the past several decades , more and more patients survive with chronic myocardial ischemia .
A s deaths from acute myocardial infarction have declined dramatically over the past several decades , more and more patients survive with chronic myocardial ischemia .
A s deaths from acute myocardial infarction have declined dramatically over the past several decades , more and more patients survive with chronic myocardial ischemia .
A s deaths from acute myocardial infarction have declined dramatically over the past several decades , more and more patients survive with chronic myocardial ischemia .
A s deaths from acute myocardial infarction have declined dramatically over the past several decades , more and more patients survive with chronic myocardial ischemia .
A s deaths from acute myocardial infarction have declined dramatically over the past several decades , more and more patients survive with chronic myocardial ischemia .
Local activation of renin – angiotensin – aldoste - rone system contributes to further reactive oxygen species generation and release of transforming growth factor-β ( TGF-β ) ; the latter plays a central role in fibroblast transformation into myofibroblasts and subsequent activation of matrix metal - loproteinases ( MMPs ) , tissue inhibitors of metalloproteinases ( TIMPs ) , and synthesis of collagens .
Local activation of renin – angiotensin – aldoste - rone system contributes to further reactive oxygen species generation and release of transforming growth factor-β ( TGF-β ) ; the latter plays a central role in fibroblast transformation into myofibroblasts and subsequent activation of matrix metal - loproteinases ( MMPs ) , tissue inhibitors of metalloproteinases ( TIMPs ) , and synthesis of collagens .
Local activation of renin – angiotensin – aldoste - rone system contributes to further reactive oxygen species generation and release of transforming growth factor-β ( TGF-β ) ; the latter plays a central role in fibroblast transformation into myofibroblasts and subsequent activation of matrix metal - loproteinases ( MMPs ) , tissue inhibitors of metalloproteinases ( TIMPs ) , and synthesis of collagens .
All Topics