MicroRNAs in the regulation of interfacial behaviors of MSCs cultured on microgrooved surface pattern.

@article{Wang2011MicroRNAsIT,
  title={MicroRNAs in the regulation of interfacial behaviors of MSCs cultured on microgrooved surface pattern.},
  author={Ying Wang and Xian-Li Jiang and Shih-Chi Yang and Xiao Lin and Yu He and Chao Yan and Li Wu and Guo-Qiang Chen and Zheyao Wang and Qiong Wu},
  journal={Biomaterials},
  year={2011},
  volume={32 35},
  pages={9207-17}
}
Cell-substrate interaction is one of the most important aspects of tissue engineering. Changes of MSCs interfacial behaviors were found to be triggered by 10 μm wide grooved pattern on poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx). Global marker genes expression and miRNAs profiling analysis provided insights into the regulation network of the topography induced MSCs' cell responses including adhesion, proliferation, differentiation and apoptosis. Compared to MSCs cultured on the… CONTINUE READING

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