MicroRNAs in spent blastocyst culture medium are derived from trophectoderm cells and can be explored for human embryo reproductive competence assessment.

@article{Capalbo2016MicroRNAsIS,
  title={MicroRNAs in spent blastocyst culture medium are derived from trophectoderm cells and can be explored for human embryo reproductive competence assessment.},
  author={Antonio Capalbo and Filippo Maria Ubaldi and Danilo Cimadomo and Laila Noli and Yakoub Khalaf and Alessio Farcomeni and Dusko Ilic and Laura F Rienzi},
  journal={Fertility and sterility},
  year={2016},
  volume={105 1},
  pages={225-35.e1-3}
}
OBJECTIVE To assess whether extracellular microRNAs (miRNAs) can be accurately profiled from spent blastocyst culture media (SBM) and used as embryonic biomarkers. DESIGN Prospective cohort study. SETTING Private and academic in vitro fertilization centers. PATIENT(S) Inner cell mass-free trophectoderm (TE) samples and their relative SBM from five good-quality human blastocysts. INTERVENTION(S) Protocol for miRNA purification and analysis based on quantitative polymerase chain reaction… CONTINUE READING
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