MicroRNAs in kidney physiology and disease

  title={MicroRNAs in kidney physiology and disease},
  author={Piera Trionfini and Ariela Benigni and Giuseppe Remuzzi},
  journal={Nature Reviews Nephrology},
MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression. They have important roles during kidney development, homeostasis and disease. In particular, miRNAs participate in the onset and progression of tubulointerstitial sclerosis and end-stage glomerular lesions that occur in various forms of chronic kidney disease (CKD). Therefore, miRNAs represent potential new therapeutic targets for a debilitating disease that continues to increase in prevalence worldwide and for… CONTINUE READING